HSDB 2967
Alginic Acid
CAS: 9005-32-7
Molecular Formula: (C6H8O6)n
HSDB 2967 - Names and Identifiers
| Name | Alginic Acid |
| Synonyms | Sazzio sazzio Kelacid norgine Norgine kelacid A 2830-9 Alginate HSDB 2967 landalgine Landalgine CCRIS 6769 Protanal LF Alginic Acid ALGINIC ACID Verdyol Super Acid Algin G 2 Satialgine-H 8 UNII-8C3Z4148WZ Snow acid algin G polymannuronicacid Polymannuronic acid Alginic acid ammonium beta-D-mannopyranuronic acid Alginic acid from brown algae, AR methyl 4-O-(4-O-methylhexopyranuronosyl)hexopyranosiduronic acid |
| CAS | 9005-32-7 |
| EINECS | 232-680-1 |
| InChI | InChI=1/C14H22O13/c1-23-7-3(15)6(18)14(27-9(7)11(19)20)25-8-4(16)5(17)13(24-2)26-10(8)12(21)22/h3-10,13-18H,1-2H3,(H,19,20)(H,21,22) |
HSDB 2967 - Physico-chemical Properties
| Molecular Formula | (C6H8O6)n |
| Molar Mass | 176.12 |
| Density | 1.67g/cm3 |
| Melting Point | 300 °C |
| Boling Point | 732.5°C at 760 mmHg |
| Flash Point | 267.8°C |
| Water Solubility | Insoluble in water. |
| Solubility | H2O: insoluble, but swells |
| Vapor Presure | 9.08E-25mmHg at 25°C |
| Appearance | White or bright yellow powder |
| Color | White to pale yellow to beige |
| Merck | 14,242 |
| Storage Condition | Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | 1.595 |
| MDL | MFCD00081309 |
| Physical and Chemical Properties | White to yellowish brown fibrous granules and powder. Odorless and tasteless, or with a slight special smell and taste. Insoluble in cold water, easily soluble in alkaline solution, insoluble in organic solvents. The pH value of 3% aqueous suspension is 2.0~3.4. When calcium salt precipitates, its sodium, potassium, ammonium or magnesium salt is dissolved in water. |
| Use | Mainly used in the pharmaceutical industry, is the main raw material for the production of cap stomach, PSS |
HSDB 2967 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | AZ5775000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 39131000 |
HSDB 2967 - Reference
| Reference Show more | 1. [IF=9.381] Xi Yang et al."Compatibility of sodium alginate and konjac glucomannan and their applications in fabricating low-fat mayonnaise-like emulsion gels."Carbohyd Polym. 2020 Feb;229:115468 |
HSDB 2967 - Standard
Authoritative Data Verified Data
This strain from a variety of brown seaweed raw materials by dilute alkali extraction of hydrophilic colloidal carbohydrate alginate, and then treated with inorganic acid, refined and obtained. The carboxylic acid group (-COOH) should be 19.0% to 25.0% based on the dry product.
Last Update：2024-01-02 23:10:35
HSDB 2967 - Trait
Authoritative Data Verified Data
- This product is white to yellowish powder; Odorless, almost tasteless.
- This product is insoluble in water, methanol, ethanol, acetone, chloroform, dissolved in sodium hydroxide solution.
Last Update：2022-01-01 11:24:55
HSDB 2967 - Introduction
Slightly soluble in hot water, very slightly soluble in cold water and organic solvents. The pH value of 3% aqueous solution is 1.3~5.5, which can absorb 200~300 times its weight of water. It can decompose slowly and reduce its molecular weight when placed under warm conditions.
Last Update：2022-10-16 17:29:53
HSDB 2967 - Differential diagnosis
Authoritative Data Verified Data
- take about 30mg of this product, add 5ml of 0. lm o l/L sodium hydroxide solution to dissolve, and add lm l of calcium chloride test solution to form colloidal precipitate.
- take about 30mg of this product, add 0. lm o l/L sodium hydroxide solution 5M l to dissolve, and add dilute sulfuric acid lm l to generate colloidal precipitate.
- take about 10mg of this product, add 5ml of water, add the new 1% 1, 3-dihydroxynaphthalene ethanol solution lm l and 5ml of hydrochloric acid, shake, boil for 5 minutes, cool, add isopropyl ether 1 5M l, shake, place for several minutes, separate the ether layer, and make a blank control, the ether layer is dark purple, and the color of the sample should be deeper than the color of the blank control.
Last Update：2022-01-01 11:24:56
HSDB 2967 - Exam
Authoritative Data Verified Data
acidity
take 1.5g of this product, add water 5 0 m l, shake for 5 minutes, and measure according to law (General rule 0631). The p H value should be 1.5~3. 5.
starch
take 0.10g of this product, add sodium hydroxide solution (1 -2500)100m] to dissolve, Take 5ml, add 1 drop of Iodine test solution, no transient blue.
chloride
take about 2.5g of this product, accurately weigh it, put it in a 100ml measuring flask, add 50m l of dilute nitric acid, shake it for 1 hour, dilute it to the scale with dilute nitric acid, shake it well, filter it, precision amount of filtrate 50ml, precision plus silver nitrate titration solution (0. lm o l/L ) 10ml and toluene 5 m l, add ammonium ferric sulfate solution 2ml, with ammonium thiocyanate titration solution (0. lm o l/L) titration, vigorously shake to the end point, and the results of the titration are corrected with a blank test. Each lm l of silver nitrate titration solution (0.1 M o l/L) corresponds to 3.545 mg of C l. No more than 1.0% of l in C.
loss on drying
take this product, in 105-C drying 4 hours, loss of weight shall not be 15. 0%(General Principles 0831).
ignition residue
take 0841g of this product, check according to law (General rule 5.0%), residue shall not exceed.
Iron Salt
take this product l .O g, first charring with small fire, then fully ash with 500 ~ 5OOt, cool, add 3M l hydrochloric acid to dissolve the residue, move to 50ml measuring flask, add water to the scale, shake well, accurately take 5ml, put it in the Nessler's colorimetric tube, add water to make 25ml, check according to law (General rule 0807), and standard iron solution 5. Compared with the control solution made of 0M l, it should not be deeper (0. 05%).
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
arsenic salt
take 0.5g of this product, add anhydrous sodium carbonate 0.5G, mix well, add a small amount of water to wet, first burn with small fire to charring, then burn at 500~600°C to Ash completely, cool, add a small amount of hydrochloric acid until the residue no longer generates bubbles, add hydrochloric acid 5ml and water 2 3 m l, according to law inspection (General Rule 0 8 2 2 2 first law), should comply with the regulations (0.0004%).
microbial limit
take this product and check it according to law (General rule 1105 and general rule 1106), and the total number of aerobic bacteria per l g of sample shall not exceed lOOcfu, the total number of molds and yeasts shall not pass lO O c fu, and Escherichia coli shall not be detected; Salmonella shall not be detected in every 10g of test article.
Last Update：2022-01-01 11:24:57
HSDB 2967 - Content determination
Authoritative Data Verified Data
take this product about 0.25g, precision weighing, add water 25ml, precision plus sodium hydroxide titration solution (0. lm o l/L ) 25ml, plus phenolphthalein indicator 0.2 m l, with hydrochloric acid titration solution (0. lm o I/L) titration. Each l of sodium hydroxide titration solution (0.1 M o l/L) corresponds to 4.502 mg of one COOH.
Last Update：2022-01-01 11:24:57
HSDB 2967 - Category
Authoritative Data Verified Data
pharmaceutical excipients, binders and disintegrants.
Last Update：2022-01-01 11:24:58
HSDB 2967 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:24:58
HSDB 2967 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| organic acid | alginic acid is a viscous organic acid, also known as alginic acid, alginic acid. The product was a white to light yellow-brown powder. The average molecular weight was about 240,000. Melting point> 300 °c. Slightly soluble in hot water, the viscosity of its aqueous solution is 4 times higher than that of starch, insoluble in cold water and organic solvents, slowly soluble in alkaline solution. No odor. It is widely found in the cell walls of hundreds of brown algae, such as macroalgae, Laminaria, Laminaria, cuticosa and sargassum, among which there are more laminaria (about 20% on average), most exist in the form of calcium and magnesium salts. alginic acid is a linear block polyuronic acid, consisting of a homo-polymerized α-L-glucopyranuronic acid block, the homo-polymerized β-D-mannuronic acid block and the cross-block of these two uronic acids are linked by 1,4-glycosidic bonds. It exists in the cell wall of many marine brown algae in the form of calcium, magnesium, sodium, potassium and strontium. Industrially, it is composed of macroalgae, Clau's kelp, Palm kelp, sugar kelp, kelp, wedge-based kelp (L. Octensis), Laminaria angustifolia (Laminaria angularis), Ascophyllum rodosum, lukhorn alga, Fucus melanocephala, extracted from empty stem Laminaria japonica and alga Pteridium sp. (Alaria), etc. The general extraction method is: raw seaweed after washing, with alkali digestion, alginic acid to produce soluble alkali metal salts, filtration, adding acid to precipitate alginic acid precipitation. Alginic acid can also be converted to sodium, potassium, ammonium, calcium salts or other organic derivatives, collectively known as aglin. Commercial alginate refers mainly to sodium alginate. free alginic acid was a white solid. Insoluble in cold water, slightly soluble in hot water. Strong acidity, with acid resistance, but easy to heat alkali decomposition. Decarboxylation occurs by the action of concentrated hydrochloric acid. Selective adsorption of metal ions, especially Fe (II) ions. Its alkali metal salts and ammonium salts are dissolved in water to form a viscous liquid, but it is not easy to form a gel. Conversion to insoluble alginic acid gels or precipitates below pH 3. The addition of polyvalent metal ions (e. G., calcium chloride) tends to gel. Sodium salt is yellowish powder, insoluble in organic solvent,[a]D-139 °. Alginate is widely used in food, textile printing and dyeing, paper making, medicine, leather, cosmetics, rubber, coatings and water treatment industries. alginic acid is mainly used as a raw material for salts such as sodium alginate and as a drug for the production of gavage. Excipients, binders and stabilizers for tablets are also used. It is often used as a thickener and emulsifier in food and cosmetics. FIG. 1 shows the chemical structural formula of alginic acid. |
| alginate | alginate is a compound extracted from brown algae. The main component thereof is a salt of alginic acid (a high molecular compound composed of polymannuronic acid and polyguluronic acid). Mainly in kelp, Sargassum and other large brown algae as raw materials, with dilute alkali dissolution of sodium salt. Soluble in water, high viscosity. Can be used in food, textile, rubber and other industries. In medicine, the pure product of oligoalginate can be formulated into "plasma substitute". Clinical trials have proved that it is effective for hemorrhagic shock, burns, scald, toxic shock, intestinal bleeding and other dehydration, it is a good expansion agent to maintain blood volume. Calcium Alginate and sodium alginate hemostatic sponges can also be prepared from sodium alginate, which can be made into hemostatic gauze with good hemostatic effect, straps and coatings for treating burn and scald. |
| sodium alginate | alginic acid and alginate are linear uronic acid glycans composed of two molecules, namely:(1) Β-(1 → 4)D-mannuronic acid (M) (2)α-(1 → 4)L-guluronic acid (G), the M/G ratio is different. The two acids are present in the same molecule and are linked to each other, and the molecular weight of the commercial sample is about 200,000. The most common is sodium alginate, but also ammonium, calcium and potassium salts. The main component of sodium alginate is the sodium salt of alginic acid, a mixture of polyuronic acids. Sodium alginate is widely used in pharmaceutical preparations, food and cosmetics, is an almost non-toxic, non-irritating substances. The gel formed by sodium alginate and calcium ions has the characteristics of freezing resistance and water absorption and swelling recovery after drying. The viscosity of sodium alginate affects the brittleness of the gel, the higher the viscosity, the more brittle the gel. The strength of the gel obtained by increasing the concentration of calcium ion and sodium alginate increases. The gelation process can be controlled by adjusting the pH, selecting a suitable calcium salt and adding a phosphate buffer or chelating agent. It can also be controlled by the gradual release of polyvalent cations or hydrogen ions, or both. The rigidity of the gel was adjusted by adjusting the ratio of sodium alginate to acid. By controlling the solubility of calcium salts, the variety and rigidity of the gel can be adjusted, and the soluble calcium chloride is used to make the gel quickly. When the Calcium dihydrogen phosphate is used, the temperature rises to 93~107 ° C to release the calcium, the gelation time can be delayed. When the amount of calcium ion added reaches 2.3%, a thick gel is obtained; When the amount is less than 1%, it is a flowing body. When the pH is close to the isoelectric point of the protein, the protein and sodium alginate form a soluble complex, and the viscosity increases, which can inhibit the precipitation of the protein. When the pH is further decreased, the complex precipitates. FIG. 2 shows the chemical structural formula of sodium alginate. |
| identification test | solubility insoluble in water and organic solvents; Slowly soluble in solutions of sodium carbonate, sodium hydroxide and trisodium phosphate. According to the OT-42 method. The pH of the 3% suspension was 2.0-3.5. According to the conventional method of measurement. Calcium chloride precipitation test a 0.5% sample solution was prepared with a sodium hydroxide solution (TS-224), and a 2.5% aqueous solution of calcium chloride in a volume of 1/5 was added. Larger volumes of gel-like precipitates should be formed. This test can be distinguished from gum arabic, carboxymethyl cellulose, carboxymethyl starch, carrageenan, gelatin, gum India, gum sinutum, Carob gum, methyl cellulose, pectin and tragacanth. Ammonium sulfate precipitation test a 0.5% sample solution was prepared with a sodium hydroxide solution (TS-224), and a saturated solution of ammonium sulfate of 1/2 volume thereof was added. Precipitation should not occur. This test can be distinguished from Agar, carboxymethylcellulose, carrageenan, low-gum pectin, gelatin, Carob gum, methylcellulose and starch. 0.1 ml of 0.15 mol/L sodium hydroxide was used for color test, and 0.01g of sample was completely dissolved as far as possible under shaking, and acid ferric sulfate test solution (TS-106)1 m1 was added. Within 5min should appear cherry red, and eventually become dark purple. |
| assay | decarboxylation method was determined as per GT-7 method. Each mL of 0.25mol/L sodium hydroxide solution consumed corresponds to mg of carbon dioxide (CO5) or 25mg of alginic acid. |
| toxicity | ADI is not specified (FAO/WHO,2001). GRAS(FDA,§ 184.1011,2000). Ld501.6 g/kg (rat, oral). |
| usage limit | FA0/WH0(1984,g/kg): canned sardines and their products 20 (based only on the filled soup); Shannon cheese 5 (based on their cream mix); Cold drink 10 (based on the final product). Soup stock and soup powder, GMP Limited (FDA,§ 184.1011,2000). GB 2760-96: gum base, GMP only. FEMA(mg/kg): Soft drink 100-240; Cold drink 2000-2400; Gel and pudding, 4000; Emulsion 100. |
| Use | stabilizer; Thickener; Emulsifier; Gel-forming agent. It can be used as thickening stabilizer of ice cream, sauce, jam, mayonnaise, soup, bread, cake, raw cream, noodles, dry noodles and instant noodles; Thawing regulator of frozen food soft drink suspension; baking coating agents; Emulsifiers for pudding, spray-dried milk powder. excipients, disintegrants, binders and stabilizers for tablets used in the pharmaceutical industry for the manufacture of geliac medicine; Often used as stabilizers, thickeners, emulsifiers and the like in foods and cosmetics. In application, it is generally processed to the sodium salt. mainly used in the pharmaceutical industry, is the main raw material for the production of Gai Wei Ping, PSS emulsifier. Protective colloid. As pharmaceutical excipients, used as binders, disintegrating agents, thickening agents, suspending agents. A colloidal substance obtained from seaweed, which is a polymer of β-anhydrous d-mannuronic acid. Emulsifiers. Protective colloid. |
| production method | alginic acid is widely found in the cell walls of hundreds of brown algae, such as giant algae, kelp, most exist in the form of calcium and magnesium salts. Alginic acid is prepared by extracting the above-mentioned algae with an aqueous solution of sodium carbonate, followed by purification with hydrochloric acid or calcium chloride. The process is as follows: the kelp after extraction of iodine is added with sodium carbonate, heated to 60-80 ° C., and stirred for 2H, so that the calcium alginate in the kelp forms a sodium salt and is dissolved in water. A small amount of formaldehyde was added to fix the pigment to improve the color of the finished product. Extract boiling solution, diluted with water. Coarse filtration through a 30-mesh sieve. The slag was removed by emulsion floating method. Then fine filtration through 100 mesh sieve to obtain crude filtrate. Hydrochloric acid was added to the fine filtrate to pH = 2 to free sodium alginate to precipitate alginic acid in the form of a gel, and 5% calcium chloride was added to promote dehydration of the gel. Press the filter with a press press, so that the water content of the alginate gel is less than 75%. with a variety of brown algae (such as kelp, giant algae, etc.) with dilute hydrochloric acid acidic water wash, to remove the attached iodine, mannitol, salt, Laminine, fucoidan, etc, it is then extracted by stirring with sodium hydroxide or sodium carbonate solution. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-rat LD50: 1600 mg/kg; Intraperitoneal-mouse LD50: 1000 mg/kg |
| flammability hazard characteristics | flammability; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:22:08
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